The socioeconomic impact of Amyotrophic Lateral Sclerosis (ALS) is significant due to the high costs of medical care and the loss of productivity. The average annual cost for an ALS patient can range from $30,000 to over $200,000, depending on the severity of the disease and care required, including hospital visits, assistive devices, and home care. Patients typically lose their ability to work within two years of diagnosis, leading to household income losses, while family members who become caregivers also face financial strain. In the U.S., ALS patients often rely on disability benefits and Medicare, adding pressure to public welfare systems. The emotional toll on families can further lead to increased mental health care costs, adding to the overall burden. Globally, the cost of ALS is estimated to reach billions annually due to these factors.